The North and Central Texas Clinical and Translational Science Initiative will be led by the University of Texas Southwestern Medical School at Dallas and will include schools of allopathic and osteopathic medicine, dentistry, nursing, pharmacy, public health, engineering and computer science, which have already formed relationships supported by a Roadmap K12 award. A new Department of Clinical Sciences, which is supported by faculty from all participating schools, will serve as the academic home for the CTSA site. Existing infrastructure and support include: a substantial financial commitment of participating institutions to the Initiative; more than 200 established clinical and translational investigators who will act as faculty and mentors; and a large and medically diverse patient base cared for by established hospitals.